BDBM50277665 4-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yloxy)benzonitrile::5-(4-cyanophenoxy)-2,3-dihydro-1-hydroxy-2,1-benzoxaborole::AN-2728::CHEMBL484785::Crisaborole::Eucrisa

SMILES OB1OCc2cc(Oc3ccc(cc3)C#N)ccc12

InChI Key InChIKey=USZAGAREISWJDP-UHFFFAOYSA-N

Data  22 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50277665   

LigandPNGBDBM50277665(4-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl...)
Affinity DataIC50:  110nMAssay Description:Inhibition of human PDE4 catalytic domain expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50277665(4-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl...)
Affinity DataIC50:  55nMAssay Description:Inhibition of PDE4B1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50277665(4-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl...)
Affinity DataIC50:  55nMAssay Description:Inhibition of PDE4B2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50277665(4-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl...)
Affinity DataIC50:  57nMAssay Description:Inhibition of PDE4B (unknown origin) assessed as hydrolysis of [3H]-cGMP into [3H]-GMP incubated for 30 mins by scintillation of proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50277665(4-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl...)
Affinity DataIC50:  7.00E+4nMAssay Description:Inhibition of PDE4B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed